Department of Physics & Astronomy
Ryu, Je-Kyung Assistant Professor
Office : 56-421 , +82-2-880-1326
Lab. : 22-416 (Protein Structural Dynamics)




  • · 2014, Ph.D. in Physics, Korea Advanced Institute of Science and Technology (KAIST)
  • · 2006, B.S. in Mathematics (Double major Physics), KAIST


  • · 2022–present Assistant professor, Seoul National University
  • · 2021–2021 Research professor, Korea Advanced Institute of Science and Technology
  • · 2017-2019 Marie Sklodowska-Curie fellow, Delft University of Technology
  • · 2016–2021 Postdoctoral researcher, KAVLI Institute, Delft University of Technology
  • · 2014–2015 Postdoctoral researcher, Korea Advanced Institute of Science and Technology

Research Interests

Using HS-AFM and various single-molecule measurements such as single-molecule fluorescence imaging and magnetic tweezers, we study the structural dynamics of chromosome-organizing proteins and membrane proteins for various cellular processes.

Selected Publications in the last 5 years

  1. Je-Kyung Ryu, Sang-Hyun Rah, Richard Janissen, Jacob W. Karppenmakers, and Cees Dekker, “Resolving the step size in condensin-driven DNA loop extrusion identifies ATP binding as the step-generating process”, Nucleic Acids Research (Impact factor: 16.971), gkab1268, (2021).
  2. Je-Kyung Ryu, Celine Bouchoux, Hon Wing Liu, Eugene Kim, Masashi Minamino, Ralph de Groot, Allard Katan, Andrea Bonato, Davide Marenduzzo, Davide Michieletto, Frank Uhlmann, and Cees Dekker, “Phase separation induced by cohesin SMC complexes”, Science Advances, 7(7), eabe5905 (2021).
  3. Je-Kyung Ryu, Allard Katan, Eli van der Sluis, Thomas Wisse, Jaco van der Torre, Ralph de Groot, Christian Haering, and Cees Dekker, “The condensin holocomplex cycles dynamically between open and collapsed states”, Nature Structural Molecular Biology, 27(12), 1134-1141 (2020).
  4. Je-Kyung Ryu, Soo Jin Kim, Sang-Hyun Rah, Ji In Kang, Hi Eun Jung, Heung-Kyu Lee, Jie-Oh Lee, Beom Seok Park, Tae-Young Yoon, and Ho Min Kim, “Reconstruction of LPS transfer cascade reveals structural determinants within LBP, CD14 and TLR4-MD2 for efficient LPS recognition and transfer”, Immunity (Impact factor: 31.745), 46(1), 38-50 (2017).
  5. Je-Kyung Ryu, Duyoung Min, Sang-Hyun Rah, Soo Jin Kim, Yongsoo Park, Haesoo Kim, Changbong Hyeon, Ho Min Kim, Reinhard Jahn & Tae-Young Yoon “Spring-loaded unraveling of a single SNARE complex by NSF in one round of ATP turnover”, Science, 347(6229), 1485-1489 (2015).