Department of Physics & Astronomy

Phase Transitions of Biopolymers

February 15, 2023l Hit 135
Date : March 22, 2023 16:00 ~
Speaker : 최정모 (부산대학교 화학과)
Professor : Prof. Dohun Kim, Prof. Sunghoon Jung
Location : 56동105호+온라인 중계

In the last decade, there has been a growing interest on the phase behavior of biomolecules, especially after demonstration of its biological implications such as reversible formation/dissociation of membrane-less cellular organelles. Several model systems have been discovered and studied, and one of crucial questions in the field is how the phase behavior is encoded in a sequence of a heteropolymer. Inspired by observations on a subset of disordered proteins that apparently exhibit a rather simple molecular grammar for phase behavior, we developed stickers-and-spacers framework adapted from the field of associative polymers for understanding how multivalent protein and RNA molecules drive phase transitions that give rise to biomolecular condensates. In this talk, I will introduce the framework and discuss its applications in explanation and prediction of biomolecular phase behaviors.