Interfaces between crystalline materials have been an essential engineering platform for modern electronics. At the interfaces formed by stacking two different two-dimensional (2D) van der Waals (vdW) crystals, one can freely control the stacking angle between the two layers to create an artificial moire superlattice and access the exotic electronic states. More interestingly, the interplay between interlayer commensurability and intralayer lattice distortion induces atomic scale reconstruction at the interface, creating arrays of commensurate domains with emergent physical functionalities. In this talk, we will discuss how one can design and engineer the atomic scale reconstruction at the interface to imprint novel functionalities. We will also discuss the experimental methodology of combining atomic resolution electron microscopy and modern semiconductor device fabrication technique to elucidate the connection between crystal symmetry and engineered domain structures with the emergent functionalities.