Mechanobiology is an interdisciplinary field which merges the older science of mechanics with the newer and emerging disciplines of molecular, cellular biology and genetics. At the center of mechanobiology is the cellular process of mechanotransduction, or the way cells sense and respond to various mechanical forces. Many, if not most, of the tissues in our body are mechano-sensitive, which include osteocytes in bone, chondrocytes in cartilage, endothelial cells in blood vessels, and epithelial cells in various tissues. In this talk, a few examples of these mechano-sensitive cells under the influence of shear, tensile, and electrical stimulations will be discussed. We investigate how these mechanical (more broadly physical) stimuli control the genetic program of a living cell to exhibit different phenotypes in relation to pathological conditions such as cancer.