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Department of Physics & Astronomy

Phase Transitions of Biopolymers

2023-02-15l 조회수 504
일시 : 2023-03-22 16:00 ~
연사 : 최정모 (부산대학교 화학과)
담당 : Prof. Dohun Kim, Prof. Sunghoon Jung
장소 : 56동105호+온라인 중계

In the last decade, there has been a growing interest on the phase behavior of biomolecules, especially after demonstration of its biological implications such as reversible formation/dissociation of membrane-less cellular organelles. Several model systems have been discovered and studied, and one of crucial questions in the field is how the phase behavior is encoded in a sequence of a heteropolymer. Inspired by observations on a subset of disordered proteins that apparently exhibit a rather simple molecular grammar for phase behavior, we developed stickers-and-spacers framework adapted from the field of associative polymers for understanding how multivalent protein and RNA molecules drive phase transitions that give rise to biomolecular condensates. In this talk, I will introduce the framework and discuss its applications in explanation and prediction of biomolecular phase behaviors.

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