Research in nanomaterials and microelectronics technologies have driven important advances in healthcare in recent years. However, the mechanical and geometrical constraints inherent in all standard forms of rigid electronics impose unique integration and therapeutic delivery challenges for wearable medical devices. Here, we describe novel materials and design constructs for multifunctional wearable electronic devices [1,2], which incorporate arrays of single crystal silicon and inorganic solid-state sensors (e.g. strain gauges, temperature sensors) and actuators (e.g. resistive heaters), coupled with important new approaches for integrating nonvolatile memory with uniform-sized nanoparticles (for portable data storage with low power consumption) and nanoparticle-based drug release mechanisms (for transdermal drug delivery). Quantitative analyses of heat-transfer, drug-diffusion, and electronic performances of these systems during mechanical deformations and under moisturized circumstances validate the individual components, thereby enabling system-level functions. These systems [2] combine advances in sensing, data storage, and drug-based feedback therapy to create new opportunities and directions in translational medicine.